2. Signaling Pathways
  3. Anti-infection
  4. Parasite

Parasite

Parasite

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Antiparasitics are a class of medications which are indicated for the treatment of parasitic diseases such as nematodes, cestodes, trematodes, and infectious protozoa.

Parasite Isoform Specific Products:

Parasite Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N0059S1
    D-Arabinose-13C-1
    		Inhibitor
    D-Arabinose-13C-1 is the 13C labeled D-Arabinose (HY-N0059). D-Arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC50 is 7.5 mM). D-Arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-Arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-Arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal AXIN-LKB1-AMPK pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-Arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082).
    D-Arabinose-<sup>13</sup>C-1
  • HY-114521
    5-(4-Methoxyphenyl)oxazole
    		Inhibitor
    5-(4'-Methoxyphenyl)-oxazole is a Caenorhabditis elegans hatch and growth inhibitor that isolated from fungal culture broth.
    5-(4-Methoxyphenyl)oxazole
  • HY-121647
    Nopol
    		Inhibitor
    Nopol is a quinoline derivative based on nopol that has inhibitory activity against the asexual blood stage of Plasmodium falciparum. Derivatives with different structures have different activities against different Plasmodium strains, and some derivatives have submicromolar EC50 values in specific strains.
    Nopol
  • HY-10373A
    Trimetrexate trihydrochloride
    		Inhibitor
    Trimetrexate (CI-898) trihydrochloride is an antibiotic, also a potent and orally active dihydrofolate reductase (DHFR) inhibitor, reducing the production of DNA and RNA precursors and leading to cell death, with IC50 values of 4.74 nM and 1.35 nM for human DHFR and Toxoplasma gondii DHFR. Trimetrexate trihydrochloride can also inhibit the growth of various cancer cells. Trimetrexate trihydrochloride can be used for researching Pneumocystis carinii pneumonia (PCP) and cancer.
    Trimetrexate trihydrochloride
  • HY-W754303
    Dihydroartemisinin-13C,d5
    Dihydroartemisinin-13C,d5 (Dihydroqinghaosu-13C,d5) is the deuterium labeled and 13C-labeled Dihydroartemisinin (HY-N0176). Dihydroartemisinin is a potent anti-malaria agent.
    Dihydroartemisinin-<sup>13</sup>C,d<sub>5</sub>
  • HY-147003
    MMV687807
    		Inhibitor
    MMV687807 is an anthelmintic agent which has a good activity against Toxoplasma gondii (T. gondii) with an IC50 value of 0.15 μM and a CC50 value of 1.69 μM.
    MMV687807
  • HY-147765
    Anti-Trypanosoma cruzi agent-3
    		Inhibitor
    Anti-Trypanosoma cruzi agent-3 (Compound 7c) is an antiprotozoal agent.
    Anti-Trypanosoma cruzi agent-3
  • HY-162072
    PfThrRS-IN-1
    PfThrRS-IN-1 (compound 11) is a potent inhibitor of Plasmodium falciparum threonyl tRNA synthetase (PfThrRS), with the IC50 value of 0.1 μM. PfThrRS-IN-1 is a potent antimalaria agent.
    PfThrRS-IN-1
  • HY-N10190
    Asperaculane B
    		Inhibitor
    Asperaculane B is a fungal metabolite against P. falciparum transmission with an IC50 of 7.89 µM. Asperaculane B also inhibits the development of asexual P. falciparum with IC50 of 3 µM, and it is nontoxic to human cells.
    Asperaculane B
  • HY-P3100
    Orfamide A
    		Inhibitor
    Orfamide A is a major metabolite of insecticidal biosurfactant in Pseudomonas sp. F6 and has aphidicidal activity. Orfamide A can be used for aphid control in organic agriculture. Orfamide A exhibits dose-dependent mortality against aphids with an LC50 value of 34.5 μg/mL.
    Orfamide A
  • HY-N0059S
    D-Arabinose-13C
    		Inhibitor
    D-Arabinose-13C is the 13C labeled D-Arabinose (HY-N0059). D-Arabinose is is an orally active antidepressant and a growth inhibitor of C. elegans (IC50 is 7.5 mM). D-Arabinose can penetrate the blood-brain barrier, selectively interfere with the metabolism of D-ribose and D-fructose, and inhibit the growth of nematodes. D-Arabinose can also inhibit the synthesis of cell biofilm and exert antibacterial activity. D-Arabinose activates the ACSS2-PPARγ/TFEB-CRTC1 axis through the lysosomal AXIN-LKB1-AMPK pathway, inducing CRTC1 transcription, exerts antidepressant-like activity. D-Arabinose is the ring-opened form of the aldopentose D-?Arabinose (HY-N7082).
    D-Arabinose-<sup>13</sup>C
  • HY-N10368
    Shinjulactone M
    		Inhibitor
    Shinjulactone M is a quassinoid isolated from various parts of Ailanthus species. Ailanthus, an important genus of the Simaroubaceae family, can be used as an febrifuge (antimalarial) and anthelmintic, and is given for the research of chronic bronchitis, epilepsy and asthma.
    Shinjulactone M
  • HY-119766
    Aramite
    		Inhibitor
    Aramite is a miticide and pesticide.
    Aramite
  • HY-W740048
    Quinine-d3
    Quinine-d3 is the deuterium labeled Quinine (HY-D0143). Quinine is an alkaloid derived from the bark of the cinchona tree, acts as an anti-malaria agent. Quinine is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100?mV with an IC50 of 169 μM.
    Quinine-d<sub>3</sub>
  • HY-N12452
    Myrrhterpenoid O
    		Inhibitor
    2604667-43-6
    Myrrhterpenoid O
  • HY-N10695
    Celangulatin C
    		Inhibitor
    Celangulatin C is an insecticidal sesquiterpene polyol ester, that can be isolated from the root bark of Pseudolarix kaempferi. Celangulatin C shows LD50 against Mythimna separata of 280.4 μg/mL.
    Celangulatin C
  • HY-N1584BR
    Halofuginone hydrochloride (Standard)
    		Inhibitor
    Halofuginone (hydrochloride) (Standard) is the analytical standard of Halofuginone (hydrochloride). This product is intended for research and analytical applications. Halofuginone (RU-19110) hydrobromid, a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM. Halofuginone hydrobromid is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity. Halofuginone hydrobromid is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca2+ channels. Halofuginone hydrobromid has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects[4].
    Halofuginone hydrochloride (Standard)
  • HY-W718785
    Clofentezine-d8
    Clofentezine-d8 is the deuterium labeled Clofentezine (HY-B2066). Clofentezine is a growth inhibitor that is highly lethal to mites.
    Clofentezine-d<sub>8</sub>
  • HY-B0273S1
    Sulfadiazine-13C6
    		Inhibitor
    Sulfadiazine-13C6 is a labeled Sulfadiazine (HY-B0273). Sulfadiazine is a sulfonamide?antibiotic with antimalarial activity[1].
    Sulfadiazine-<sup>13</sup>C<sub>6</sub>
  • HY-147536
    Antileishmanial agent-8
    		Inhibitor
    Antileishmanial agent-8 (compound 18) has potent and selective activity against Leishmania donovani (L. donovani) with an IC50 value of 5.64 μM. Antileishmanial agent-8 has relatively low cytotoxicity in L-6 cells (IC50=73.9 μM).
    Antileishmanial agent-8
Parasite Isoform Comparison

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