2. Signaling Pathways
  3. Anti-infection
  4. Parasite

Parasite

Parasite

Related Products

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Antiparasitics are a class of medications which are indicated for the treatment of parasitic diseases such as nematodes, cestodes, trematodes, and infectious protozoa.

Parasite Isoform Specific Products:

Parasite Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-169289
    PIQ-2
    		Inhibitor
    PIQ-2 (compound 54) is a antiprotozoal agent with the IC50 values of 9.4 nM and 1.6 nM against IP. falciparum 3D7I and B. divergens Rouen,respectively.
    PIQ-2
  • HY-N8465
    Noracronycine
    		Inhibitor
    Noracronycine is an alkaloid originally isolated from G. pentaphylla that has antimalarial activity. It is active against P. yoelii when used at a concentration of 10 μg/mL.
    Noracronycine
  • HY-B0846S
    Dimethomorph-d8
    Dimethomorph-d8 is the deuterium labeled Dimethomorph. Dimethomorph is a fungicide belongs to the fungicide group of sterol biosynthesis inhibitor. Dimethomorph can inhibit fungal cell wall formation. Dimethomorph also inhibits androgen receptor (AR) activity in MDA-kb2 cells with an IC20 of 0.263 μM.
    Dimethomorph-d<sub>8</sub>
  • HY-163560
    Insecticidal agent 10
    		Inhibitor
    Insecticidal agent 10 (Compound 8c) is an inhibitor for chitinase, which inhibits OfChi-h and OfChtI with IC50 of 1.51 and 9.21 nM, respectively. Insecticidal agent 10 inhibits growth of Ostrinia furnacalis with LC50 of 22.14 mg/L.
    Insecticidal agent 10
  • HY-168184
    WJM280
    		Inhibitor
    WJM280 is an orally active antimalarial agent, with an EC50 of 0.04 μM for P. falciparum 3D7 parasites.
    WJM280
  • HY-17589S
    Chloroquine-d5 diphosphate
    		Inhibitor
    Chloroquine-d5 (diphosphate) is the deuterium labeled Chloroquine (phosphate). Chloroquine phosphate is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine phosphate is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine phosphate is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC50=1.13 μM).
    Chloroquine-d<sub>5</sub> diphosphate
  • HY-131433
    Teroxalene hydrochloride
    		Inhibitor
    Teroxalene hydrochloride is an orally active schistosomiasis agent.
    Teroxalene hydrochloride
  • HY-W703432
    α-Artemether-d3
    α-Artemether-d3 (Methoxy-d3) is the deuterium labeled α-Artemether (HY-137217). α-Artemether is an antimalarial compound.
    α-Artemether-d<sub>3</sub>
  • HY-N8513
    Brevicompanine B
    		Inhibitor
    Brevicompanine B, a diketopiperazine alkaloid, is an antiplasmodial agent. Brevicompanine B is active against the malaria parasite Plasmodium falciparum 3D7 IC50 of 35 mg/mL.
    Brevicompanine B
  • HY-155334
    RyRs activator 4
    		Inhibitor
    RyRs activator 4 (compound B18) is an insect ryanodine receptor activator. RyRs activator 4 has a larvicidal activity of Mythimna separata with an LC50 value of 1.32 mg/L.
    RyRs activator 4
  • HY-B0263S1
    Thiabendazole-13C6
    		Inhibitor
    Thiabendazole-13C6 is the 13C6 labeled Thiabendazole. Thiabendazole inhibites the mitochondrial helminth-specific enzyme, fumarate reductase, with anthelminthic property.
    Thiabendazole-<sup>13</sup>C<sub>6</sub>
  • HY-159479
    PfSUB1-IN-1
    		Inhibitor
    PfSUB1-IN-1 (compound 4c) is a plasmodium falciparum subtilisin-like serine protease 1 (PfSUB1) Inhibitor (IC50: 15 nM). PfSUB1 is an antimalarial target. PfSUB1-IN-1 inhibits the growth of a genetically modified P. falciparum line expressing reduced levels of PfSUB1 13-fold more efficiently compared to a wild-type parasite line.
    PfSUB1-IN-1
  • HY-141836
    MMV666810
    		Inhibitor
    MMV666810, a 2-aminopyrazine similar to MMV390048, is potent against asexual parasites at 5.94 nM, but against gametocytes, it has a 3.3-fold selectivity to late-stage gametocytes compared to earlier stages (early-stage gametocyte: IC50 603 ± 88 nM; late-stage gametocyte: IC50 179 ± 8 nM).
    MMV666810
  • HY-B2041R
    Benfuracarb (Standard)
    Benfuracarb (Standard) is the analytical standard of Benfuracarb. This product is intended for research and analytical applications. Benfuracarb is a broad-spectrum carbamate insecticide with crop protection activity. Benfuracarb is used to control springtails, aphids, and other pests, typically on sugar beet crops. Benfuracarb exhibits toxicity to humans and aquatic organisms. Benfuracarb exposure to zebrafish embryos resulted in a reduction in the body length of zebrafish larvae. Superoxide dismutase (SOD) activity was significantly increased after Benfuracarb treatment. Benfuracarb also interfered with the transcriptional levels of marker genes associated with early embryonic development.
    Benfuracarb (Standard)
  • HY-162778
    FM-1088
    FM-1088 is an insecticide. FM-1088 can be used in research related to crop disease and insect pest control.
    FM-1088
  • HY-12784AR
    Cycloguanil (hydrochloride) (Standard)
    		Inhibitor
    Cycloguanil (hydrochloride) (Standard) is the analytical standard of Cycloguanil (hydrochloride). This product is intended for research and analytical applications. Cycloguanil hydrochloride, the active metabolite of Proguanil, acts on malaria schizonts in erythrocytes and hepatocytes.
    Cycloguanil (hydrochloride) (Standard)
  • HY-151935
    Antileishmanial agent-13
    		Inhibitor
    Antileishmanial agent-13 is a quinoline-isatin hybrid, acts as an antileishmanial agent against L. Major Leishmania strain. Antileishmanial agent-13 acquires the antileishmanial activity via the anti-folate mechanism. Antileishmanial agent-13 has potent inhibition against both promastigote and amastigote forms with IC50s of 0.604 μM and 0.508 μM, respectively.
    Antileishmanial agent-13
  • HY-N11550
    Salviandulin E
    		Inhibitor
    Salviandulin E is a diterpenoid compound that can be isolated from Salvia leucantha CAV.. Salviandulin E shows antitrypanosomal activity against T. b. brucei GUTat 3.1 parasites with an IC50 value of 0.72 µg/mL.
    Salviandulin E
  • HY-149980
    DCN-83
    		Inhibitor
    DCN-83, an anti-leishmania agent, is most potent against the amastigote form with an IC50 of 0.71 μM. DCN-83 has the potential to cross the blood-brain barrier and central nervous system.
    DCN-83
  • HY-149919
    Antimalarial agent 23
    		Inhibitor
    Antimalarial agent 23 is an antimalarial benzimidazole with IC50s of 0.08 μM and 0.10 μM for PfNF54 and PfK1, respectively. Antimalarial agent 23 has potent β-hematin inhibition activity. Antimalarial agent 23 does not directly inhibit the conversion of heme to hemozoin.
    Antimalarial agent 23
Parasite Isoform Comparison

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